D(1A) dopamine receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13D(1A) dopamine receptor shows approved-linked disease relevance led by hemorrhage. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P21728. Start with hemorrhage, then reuse UniProt P21728 as the stable protein anchor across project notes and exports.
Start with hemorrhage, then reuse UniProt P21728 as the stable protein anchor across project notes and exports.
D(1A) dopamine receptor shows approved-linked disease relevance led by hemorrhage. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with hemorrhage because it currently carries approved-linked support. Linked drugs include METHYLERGONOVINE MALEATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyD(1A) dopamine receptor
Review this target as D(1A) dopamine receptor, mapped to UniProt P21728. Sequence length is 446 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats D(1A) dopamine receptor as ChEMBL target CHEMBL2056, mapped to UniProt P21728. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether D(1A) dopamine receptor is the right protein anchor across sources, using UniProt P21728 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hemorrhage is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | D(1A) dopamine receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P21728 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | D(1A) dopamine receptor |
| UniProt Accession | P21728 |
| Component Type | Protein |
| Sequence Length | 446 aa |
D(1A) dopamine receptor
Review this target as D(1A) dopamine receptor, mapped to UniProt P21728. Sequence length is 446 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
D(1A) dopamine receptor shows approved-linked disease relevance led by hemorrhage. 5 more disease programs remain visible in the same review block.
Start review with hemorrhage because it currently carries approved-linked support. Linked drugs include METHYLERGONOVINE MALEATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1814790 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL62 | 9.96 | Ki | 0.11 | Preclinical |
| CHEMBL1196161 | 9.92 | EC50 | 0.12 | Preclinical |
| CHEMBL3039528 | 9.89 | Ki | 0.13 | Clinical |
| CHEMBL434215 | 9.82 | Kd | 0.15 | Preclinical |
| CHEMBL1256645 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL574558 | 9.7 | EC50 | 0.2 | Preclinical |
| CHEMBL596824 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL599135 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL599528 | 9.7 | Ki | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 449 | 475 | 6.9 |
| cell-based format | 168 | 661 | 6.8 |
| cell membrane format | 17 | 97 | 6.0 |
| assay format | 15 | 198 | 7.2 |
| organism-based format | 5 | 0 | — |
| tissue-based format | 3 | 20 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 128 | 251 | 7.0 |
| assay format | 36 | 31 | 7.3 |
| single protein format | 3 | 3 | 6.7 |
| tissue-based format | 3 | 37 | 7.4 |
| cell membrane format | 1 | 1 | 4.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 8 | 1 | 7.9 |
| single protein format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |