Compound Detail
CHEMBL588
FENOLDOPAM 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL588 |
| Name | FENOLDOPAM |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | TVURRHSHRRELCG-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
11
Targets
23
Activities
4
Assay Types
0
PK Parameters
20
Publications
4
Known Names
5
Indications
Molecular Properties
305.8
MW (Da)
2.73
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1997 |
| Availability | Discontinued |
| Chirality | Racemic |
Indications
Cardiovascular Diseases Acute Kidney Injury Renal Insufficiency Kidney Failure, Chronic Hypertension
ATC Classification
C01CA19
fenoldopam
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
Activity Summary
Ki 9 meas. best 8.91
Kd 6 meas. best 7.55
EC50 5 meas. best 8.55
IC50 3 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(1A) dopamine receptor CHEMBL265 | Ki | 8.91 | 8.715 | 1.2 | 2 |
| D(1A) dopamine receptor CHEMBL2056 | EC50 | 8.55 | 8.025 | 2.8 | 2 |
| D(2) dopamine receptor CHEMBL339 | Ki | 7.88 | 7.88 | 13.2 | 1 |
| Rattus norvegicus CHEMBL376 | EC50 | 7.75 | 7.75 | 18.0 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | Kd | 7.55 | 7.55 | 28.0 | 1 |
| Adenosine receptor A2b CHEMBL2592 | Ki | 7.45 | 7.45 | 35.5 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | Ki | 7.4 | 7.4 | 40.0 | 1 |
| D(1A) dopamine receptor CHEMBL265 | EC50 | 7.24 | 7.24 | 57.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL2094251 | Ki | 6.82 | 6.82 | 151.4 | 1 |
| D(2) dopamine receptor CHEMBL3998 | Ki | 6.1 | 6.1 | 790.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.09 | 6.09 | 810.0 | 1 |
| Lysine-specific histone demethylase 1A CHEMBL6136 | IC50 | 6.05 | 6.05 | 890.0 | 1 |
| Oryctolagus cuniculus CHEMBL374 | EC50 | 5.92 | 5.92 | 1200.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | Kd | 5.89 | 5.5175 | 1300.0 | 4 |
| D(2) dopamine receptor CHEMBL3998 | IC50 | 5.8 | 5.8 | 1580.0 | 1 |
| Lysine-specific demethylase 4E CHEMBL1293226 | Ki | 5.72 | 5.72 | 1920.0 | 1 |
| Lysine-specific demethylase 4E CHEMBL1293226 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL2094251 | Kd | 5.3 | 5.3 | 5011.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine