Assay Detail
Binding
CHEMBL670206
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Displacement of [3H]spiroperidol from homogenized bovine pituitary Dopamine receptor D2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzothiazol-2-one 7-ethylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.92 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17231 | — | — | 1 | 7.31 |
| CHEMBL587 | SKF-89124A | — | 1 | 6.28 |
| CHEMBL279106 | — | — | 1 | 6.25 |
| CHEMBL418548 | — | — | 1 | 6.00 |
| CHEMBL275600 | — | — | 1 | 6.00 |
| CHEMBL275155 | — | — | 1 | 5.92 |
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 5.80 |
| CHEMBL17357 | — | — | 1 | 5.70 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.33 |
| CHEMBL278188 | — | — | 1 | 5.31 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 5.17 |
| CHEMBL441220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17231 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL587 | SKF-89124A | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL279106 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL418548 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL275600 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL275155 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL588 | FENOLDOPAM | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL17357 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL59 | DOPAMINE | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL278188 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL589 | ROPINIROLE | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL441220 | — | IC50 | > | 10000.0 | nM | - |