D(2) dopamine receptor · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P20288. Use UniProt P20288 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P20288 as the stable identity anchor, then attach disease evidence before program review.
D(2) dopamine receptor
Review this target as D(2) dopamine receptor, mapped to UniProt P20288. Sequence length is 444 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats D(2) dopamine receptor as ChEMBL target CHEMBL3998, mapped to UniProt P20288. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | D(2) dopamine receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P20288 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | D(2) dopamine receptor |
| UniProt Accession | P20288 |
| Component Type | Protein |
| Sequence Length | 444 aa |
D(2) dopamine receptor
Review this target as D(2) dopamine receptor, mapped to UniProt P20288. Sequence length is 444 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL123813 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL317488 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL607228 | 10.18 | Ki | 0.066 | Preclinical |
| CHEMBL332740 | 10.17 | Ki | 0.068 | Preclinical |
| CHEMBL54 | 9.52 | Ki | 0.3 | Approved |
| CHEMBL445347 | 9.25 | Ki | 0.56 | Preclinical |
| CHEMBL1423 | 9.22 | Ki | 0.6 | Approved |
| CHEMBL64878 | 9.11 | IC50 | 0.77 | Preclinical |
| CHEMBL54 | 8.92 | IC50 | 1.2 | Approved |
| CHEMBL301265 | 8.8 | Kd | 1.6 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 83 | 103 | 6.8 |
| assay format | 35 | 108 | 6.5 |
| cell membrane format | 16 | 8 | 7.0 |
| tissue-based format | 9 | 15 | 6.4 |
| cell-based format | 5 | 24 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 30 | 0 | — |