Compound Detail
CHEMBL278188
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL278188 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZAHNXSYMXOCYFR-UHFFFAOYSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
192.2
MW (Da)
0.39
ALogP
3
HBA
3
HBD
75.3
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 6.94
IC50 1 meas. best 5.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dopamine receptor CHEMBL2096905 | EC50 | 6.94 | 6.94 | 116.0 | 2 |
| Oryctolagus cuniculus CHEMBL374 | EC50 | 6.94 | 6.94 | 116.0 | 2 |
| D(1A) dopamine receptor CHEMBL265 | EC50 | 5.33 | 5.33 | 4650.0 | 1 |
| D(2) dopamine receptor CHEMBL3998 | IC50 | 5.31 | 5.31 | 4850.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dopamine receptor | EC50 | = | 116.0 | nM | 6.94 | Tested in vitro for dopamine agonist activity in rabbit ear artery after at a do... | 6306238 |
| Dopamine receptor | EC50 | = | 116.0 | nM | 6.94 | Inhibitory activity against constrictor response to electrical stimulation in th... | 4045928 |
| Oryctolagus cuniculus | EC50 | = | 116.0 | nM | 6.94 | Ability to relax the electrically stimulated rabbit ear artery was determined | 2955118 |
| Oryctolagus cuniculus | EC50 | = | 116.0 | nM | 6.94 | Ability to stimulate peripheral prejunctional dopaminergic receptors by 50% inhi... | 3712384 |
| D(1A) dopamine receptor | EC50 | = | 4650.0 | nM | 5.33 | Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-... | 2955118 |
| D(2) dopamine receptor | IC50 | = | 4850.0 | nM | 5.31 | Displacement of [3H]spiroperidol from homogenized bovine pituitary Dopamine rece... | 2955118 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6306238 | 10.1021/jm00361a001 | Canis familiaris | 6 |
| 2955118 | 10.1021/jm00390a009 | D(1A) dopamine receptor | 2 |
| 6306238 | 10.1021/jm00361a001 | Dopamine receptor | 1 |
| 4045928 | 10.1021/jm00148a028 | Dopamine receptor | 1 |
| 2955118 | 10.1021/jm00390a009 | Oryctolagus cuniculus | 1 |
| 2955118 | 10.1021/jm00390a009 | D(2) dopamine receptor | 1 |
| 3712384 | 10.1021/jm00156a010 | Oryctolagus cuniculus | 1 |
Data from ChEMBL 36 via Core Engine