Assay Detail
Binding
CHEMBL672966
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Inhibitory activity against constrictor response to electrical stimulation in the isolated perfused rabbit ear artery(REA) expressing dopamine receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone: a prejunctional dopamine receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.21 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL587 | SKF-89124A | — | 1 | 8.74 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 7.00 |
| CHEMBL278188 | — | — | 1 | 6.94 |
| CHEMBL39845 | — | — | 1 | 6.16 |
| CHEMBL284803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL587 | SKF-89124A | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL589 | ROPINIROLE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL278188 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL39845 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL284803 | — | EC50 | > | 1000.0 | nM | - |