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Target Snapshot

CHEMBL2096905 Target Snapshot

Dopamine receptor · PROTEIN FAMILY · Homo sapiens

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99Compounds
37Assays
5Approved Drugs
56.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Dopamine receptor shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P14416. Start with cardiovascular disease, then reuse UniProt P14416 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with cardiovascular disease, then reuse UniProt P14416 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
cardiovascular disease

Dopamine receptor shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with cardiovascular disease because it currently carries approved-linked support. Linked drugs include ERGOLOID MESYLATES. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Dopamine receptor as ChEMBL target CHEMBL2096905, mapped to UniProt P14416. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Dopamine receptor
PROTEIN FAMILY · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2096905
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P14416
D(2) dopamine receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Dopamine receptor is the right protein anchor across sources, using UniProt P14416 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why cardiovascular disease is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameDopamine receptor
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtP14416
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelD(2) dopamine receptor
UniProt AccessionP14416
Component TypeProtein
Sequence Length443 aa

D(2) dopamine receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Dopamine receptor, mapped to UniProt P14416. ChEMBL maps the protein component as D(2) dopamine receptor. Sequence length is 443 aa.

Mapped IDP14416
Review nameDopamine receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Dopamine receptor shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
cardiovascular disease
1 linked drug · 1 direct · 1 efficacy
Linked drugERGOLOID MESYLATES
Approved-linked Approved
major depressive disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugAMOXAPINE
Approved-linked Approved
psychosis
1 linked drug · 1 direct · 1 efficacy
Linked drugPIMOZIDE
Approved-linked Approved
Tics
1 linked drug · 1 direct · 1 efficacy
Linked drugPIMOZIDE
Approved-linked Approved
Tourette syndrome
1 linked drug · 1 direct · 1 efficacy
Linked drugPIMOZIDE
Late clinical Phase III
anxiety
1 linked drug · 1 direct · 1 efficacy
Linked drugPIMOZIDE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with cardiovascular disease because it currently carries approved-linked support. Linked drugs include ERGOLOID MESYLATES. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasecardiovascular disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

5
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC509.0
KI37.0
EC5010.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL587 8.74 EC50 1.8 Preclinical
CHEMBL54 8.3 IC50 5.0 Approved
CHEMBL8809 8.29 Ki 5.1 Clinical
CHEMBL328119 7.96 Ki 11.0 Preclinical
CHEMBL1201087 7.89 EC50 13.0 Approved
CHEMBL59 7.82 IC50 15.0 Approved
CHEMBL273273 7.8 IC50 16.0 Preclinical
CHEMBL80127 7.76 Ki 17.3 Preclinical
CHEMBL92578 7.7 Ki 20.0 Preclinical
CHEMBL327263 7.68 Ki 21.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
4
5.5
6
6.0
11
6.5
9
7.0
8
7.5
3
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

APOMORPHINE
CHEMBL53
Approved 2001
Properties Compare Identifier
ROPINIROLE
CHEMBL589
Approved 1997
Properties Compare Identifier
CABERGOLINE
CHEMBL1201087
Approved 1996
Properties Compare Identifier
DOPAMINE
CHEMBL59
Approved 1974
Properties Compare Identifier
HALOPERIDOL
CHEMBL54
Approved 1967
Properties Compare Identifier
Assay Landscape

Assay Landscape

37
Total Assays
38
Tested Compounds
2
Assay Types
Binding — 30 assays, 38 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 22 11 7.4
assay format 5 10 6.9
organism-based format 2 0 —
cell-based format 1 17 6.8
Functional — 7 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 3 1 6.9
assay format 2 0 —
organism-based format 2 3 7.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine