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Target Snapshot

CHEMBL374 Target Snapshot

Oryctolagus cuniculus · ORGANISM · Oryctolagus cuniculus

5,202Compounds
3,586Assays
44Approved Drugs
2,647.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Oryctolagus cuniculus as ChEMBL target CHEMBL374. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Oryctolagus cuniculus
ORGANISM · Oryctolagus cuniculus
As of 2026-09-13
ChEMBL target ID
CHEMBL374
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Oryctolagus cuniculus still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOryctolagus cuniculus
UniProt AccessionN/A

Oryctolagus cuniculus

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Oryctolagus cuniculus.

Review nameOryctolagus cuniculus
OrganismOryctolagus cuniculus
Clinical Profile

Clinical Phase Distribution

44
Approved
13
Phase III
29
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC501,767.0
KI4.0
EC50558.0
KD318.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL281036 11.0 Kd 0.01 Preclinical
CHEMBL21536 11.0 IC50 0.01 Approved
CHEMBL281545 10.8 Kd 0.01585 Preclinical
CHEMBL448096 10.6 Kd 0.02512 Preclinical
CHEMBL17231 10.55 EC50 0.028 Preclinical
CHEMBL308148 10.48 Kd 0.03311 Clinical
CHEMBL1788194 10.24 EC50 0.057 Preclinical
CHEMBL173008 10.17 Kd 0.06761 Preclinical
CHEMBL27856 10.1 Kd 0.07943 Preclinical
CHEMBL9937 9.9 Kd 0.1259 Preclinical
Distribution

pChEMBL Value Distribution

204
5.0
303
5.5
307
6.0
253
6.5
218
7.0
210
7.5
168
8.0
127
8.5
45
9.0
25
9.5
pChEMBL
Approved Drugs

Approved Drugs

XANOMELINE
CHEMBL21536
Approved 2024
ANGIOTENSIN II
CHEMBL408403
Approved 2017
APIXABAN
CHEMBL231779
Approved 2011
FORMOTEROL
CHEMBL1256786
Approved 2001
APOMORPHINE
CHEMBL53
Approved 2001
RAMATROBAN
CHEMBL361812
Approved 2000
SILDENAFIL
CHEMBL192
Approved 1998
RIZATRIPTAN
CHEMBL905
Approved 1998
FENOLDOPAM MESYLATE
CHEMBL1026
Approved 1997
ANAGRELIDE
CHEMBL760
Approved 1997
IRBESARTAN
CHEMBL1513
Approved 1997
ROPINIROLE
CHEMBL589
Approved 1997
VALSARTAN
CHEMBL1069
Approved 1996
LOSARTAN
CHEMBL191
Approved 1995
SERATRODAST
CHEMBL70972
Approved 1995
SALMETEROL
CHEMBL1263
Approved 1994
SUMATRIPTAN
CHEMBL128
Approved 1992
AMLODIPINE
CHEMBL1491
Approved 1992
DILTIAZEM
CHEMBL23
Approved 1982
SARALASIN
CHEMBL938
Approved 1982
NITROGLYCERIN
CHEMBL730
Approved 1981
VERAPAMIL
CHEMBL6966
Approved 1981
NIFEDIPINE
CHEMBL193
Approved 1981
DOPAMINE
CHEMBL59
Approved 1974
CARBACHOL
CHEMBL14
Approved 1972
ERYTHROMYCIN
CHEMBL532
Approved 1964
Assay Landscape

Assay Landscape

3,593
Total Assays
1,903
Tested Compounds
3
Assay Types
Functional — 2,880 assays, 1,903 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 2,847 1,897 6.6
assay format 26 4 6.1
tissue-based format 7 2 5.5
ADME — 534 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 534 0
Toxicity — 179 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 171 0
assay format 8 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine