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Evidence Snapshot

Oryctolagus cuniculus

CHEMBL374 ORGANISM Oryctolagus cuniculus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T17:22:35Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL374
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Oryctolagus cuniculus as ChEMBL target CHEMBL374. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Oryctolagus cuniculus
ORGANISM · Oryctolagus cuniculus
As of 2026-09-13
ChEMBL target ID
CHEMBL374
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Oryctolagus cuniculus matters

As of 2026-09-13

Oryctolagus cuniculus is reviewed as Oryctolagus cuniculus; the current evidence base includes 44 approved drugs, 5202 compounds, and 3586 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 44 approved drugs, 5202 compounds, and 3586 assays for this target. The dominant activity type is IC50. CHEMBL281036 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL281036 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
44 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Oryctolagus cuniculus matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

5202
Total Compounds
3586
Total Assays
44
Approved Drugs
IC50: 1767.0, KI: 4.0, EC50: 558.0, KD: 318.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL281036
 11.0 Kd —
No preferred name
CHEMBL21536
 11.0 IC50 Approved
No preferred name
CHEMBL281545
 10.8 Kd —
No preferred name
CHEMBL448096
 10.6 Kd —
No preferred name
CHEMBL17231
 10.6 EC50 —

Approved Drugs

Structure Compound First Approval
XANOMELINE
CHEMBL21536
 2024
ANGIOTENSIN II
CHEMBL408403
 2017
APIXABAN
CHEMBL231779
 2011
FORMOTEROL
CHEMBL1256786
 2001
APOMORPHINE
CHEMBL53
 2001
RAMATROBAN
CHEMBL361812
 2000
SILDENAFIL
CHEMBL192
 1998
RIZATRIPTAN
CHEMBL905
 1998
FENOLDOPAM MESYLATE
CHEMBL1026
 1997
ANAGRELIDE
CHEMBL760
 1997
IRBESARTAN
CHEMBL1513
 1997
ROPINIROLE
CHEMBL589
 1997
VALSARTAN
CHEMBL1069
 1996
LOSARTAN
CHEMBL191
 1995
SERATRODAST
CHEMBL70972
 1995
SALMETEROL
CHEMBL1263
 1994
SUMATRIPTAN
CHEMBL128
 1992
AMLODIPINE
CHEMBL1491
 1992
DILTIAZEM
CHEMBL23
 1982
SARALASIN
CHEMBL938
 1982
NITROGLYCERIN
CHEMBL730
 1981
VERAPAMIL
CHEMBL6966
 1981
NIFEDIPINE
CHEMBL193
 1981
DOPAMINE
CHEMBL59
 1974
CARBACHOL
CHEMBL14
 1972
ERYTHROMYCIN
CHEMBL532
 1964
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T17:22:35Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL374