Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL408403

ANGIOTENSIN II
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL408403
Name ANGIOTENSIN II
Phase Approved
Structure Type BOTH
InChI Key CZGUSIXMZVURDU-JZXHSEFVSA-N
Therapeutic ✓ Yes

Known Names

5-l-isoleucineangiotensin ii Angiotensin ii Angiotensin ii (human type) Angiotensin ii human Angiotensina ii Angiotensine ii Asp-arg-val-tyr-ile-his-pro-phe Delivert LJPC-501
9
Targets
52
Activities
4
Assay Types
0
PK Parameters
20
Publications
9
Known Names
6
Indications

Molecular Properties

1046.2
MW (Da)

Drug Information

Molecule Type Protein
First Approval 2017
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Parenteral

Flags

Natural Product First in Class
USAN Year 2016

Extended Properties

Molecular Formula C50H71N13O12
MW 1046.20

Indications

Cardiovascular Diseases Hypertension Shock, Septic Hepatorenal Syndrome Orthostatic Intolerance Pre-Eclampsia

ATC Classification

C01CX09
angiotensin II
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY

Activity Summary

Ki 23 meas. best 10.0
IC50 17 meas. best 10.1
EC50 10 meas. best 9.31
Kd 2 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Type-2 angiotensin II receptor
CHEMBL4607
 IC50 10.1 9.1625 0.1 4
Angiotensin II receptor (AT-1) type-1
CHEMBL2094250
 Ki 10.0 9.4633 0.1 6
Type-1 angiotensin II receptor
CHEMBL227
 Ki 9.8 9.4425 0.2 4
Type-2 angiotensin II receptor
CHEMBL4607
 Ki 9.7 9.4238 0.2 8
Type-1 angiotensin II receptor B
CHEMBL263
 Ki 9.51 9.265 0.3 2
Type-1 angiotensin II receptor B
CHEMBL263
 IC50 9.4 9.4 0.4 1
Type-1 angiotensin II receptor A
CHEMBL329
 IC50 9.4 9.4 0.4 1
Type-1 angiotensin II receptor
CHEMBL227
 EC50 9.31 8.7975 0.5 4
Angiotensin II receptor (AT-1) type-1
CHEMBL2094250
 IC50 9.28 8.8783 0.5 6
Type-1 angiotensin II receptor
CHEMBL227
 IC50 9.14 8.565 0.7 2
Unchecked
CHEMBL612545
 Ki 9.02 9.02 0.9 1
Type-1 angiotensin II receptor A
CHEMBL329
 EC50 8.89 8.53 1.3 2
Angiotensin II receptor
CHEMBL2094112
 IC50 8.89 8.6633 1.3 3
Angiotensin II receptor
CHEMBL2094112
 Ki 8.86 8.79 1.4 2
Oryctolagus cuniculus
CHEMBL374
 EC50 8.85 8.595 1.4 4
Type-1 angiotensin II receptor
CHEMBL227
 Kd 8.7 8.7 2.0 1
Type-1 angiotensin II receptor
CHEMBL3374
 Kd 8.24 8.24 5.8 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Type-2 angiotensin II receptor IC50 = 0.08 nM 10.1 Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed i... 27876250
Angiotensin II receptor (AT-1) type-1 Ki = 0.1 nM 10.0 Displacement of [125I]Ang2 from AT1 receptor in rat liver membrane 17004728
Type-1 angiotensin II receptor Ki = 0.16 nM 9.8 Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed i... 26824643
Type-2 angiotensin II receptor Ki = 0.2 nM 9.7 Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium us... 16220978
Type-2 angiotensin II receptor Ki = 0.2 nM 9.7 Binding affinity to type-2 angiotensin-2 receptor (unknown origin) 26810314
Type-2 angiotensin II receptor Ki = 0.23 nM 9.64 Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus ... 15943474
Type-2 angiotensin II receptor Ki = 0.23 nM 9.64 Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig ... 14761188
Type-1 angiotensin II receptor Ki = 0.24 nM 9.62 Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Va... 26824643
Angiotensin II receptor (AT-1) type-1 Ki = 0.24 nM 9.62 Binding affinity for angiotensin II receptor type 1 using [125I]- Ang II in rat ... 14761188
Angiotensin II receptor (AT-1) type-1 Ki = 0.24 nM 9.62 Displacement of [125I]-Ang II from angiotensin II receptor type 1 in rat liver m... 15943474
Type-2 angiotensin II receptor Ki = 0.3 nM 9.52 Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane 17358051
Type-1 angiotensin II receptor B Ki = 0.31 nM 9.51 In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was deter... 11960488
Type-1 angiotensin II receptor B IC50 = 0.4 nM 9.4 Binding affinity for rat angiotensin II receptor, type 1 15115399
Type-1 angiotensin II receptor A IC50 = 0.4 nM 9.4 Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic mem... 18318468
Type-1 angiotensin II receptor EC50 = 0.4898 nM 9.31 Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Ga... 26824643
Angiotensin II receptor (AT-1) type-1 Ki = 0.5 nM 9.3 Displacement of [125I]Ang2 from AT1 receptor in rat liver membrane 17358051
Type-1 angiotensin II receptor Ki = 0.5 nM 9.3 Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutive... 20146480
Type-1 angiotensin II receptor EC50 = 0.52 nM 9.28 Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Ga... 26824643
Angiotensin II receptor (AT-1) type-1 Ki = 0.53 nM 9.28 In vitro binding affinity against Angiotensin II receptor, type 1 from rat liver... 10579816
Angiotensin II receptor (AT-1) type-1 IC50 = 0.53 nM 9.28 Compound was evaluated in a radioligand binding assay to displace [125I]-Ang II ... 10052967

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885881 Rattus norvegicus 934
23567951 10.1016/j.ejmech.2013.02.041 Unchecked 8
26824643 10.1021/acs.jmedchem.5b01495 Type-1 angiotensin II receptor 5
9379447 10.1021/jm9608669 Type-1 angiotensin II receptor 3
8709104 10.1021/jm9507744 Type-1 angiotensin II receptor 3
12182875 10.1016/s0960-894x(02)00474-2 Oryctolagus cuniculus 3
2704034 10.1021/jm00124a028 Angiotensin II receptor 2
6267278 10.1021/jm00136a002 Oryctolagus cuniculus 2
10579816 10.1021/jm991089q Angiotensin II receptor (AT-1) type-1 2
836506 10.1021/jm00212a029 Rattus norvegicus 2
25313325 10.1021/ml500278g Unchecked 2
2362273 10.1021/jm00169a019 Oryctolagus cuniculus 2
1956044 10.1021/jm00115a014 Angiotensin II receptor 2
31223447 10.1021/acsmedchemlett.9b00086 NCI-H295R 2
15943474 10.1021/jm0491492 Type-2 angiotensin II receptor 2
20146480 10.1021/jm9015747 Type-1 angiotensin II receptor 2
1920354 10.1021/jm00114a012 Angiotensin II receptor 2
10052967 10.1021/jm981077p Angiotensin II receptor (AT-1) type-1 2
490561 10.1021/jm00195a025 ADMET 2
33965531 10.1016/j.bmcl.2021.128086 Unchecked 1

Data from ChEMBL 36 via Core Engine