Assay Detail
Binding
CHEMBL1100567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.86 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1076604 | — | — | 1 | 9.52 |
| CHEMBL1076602 | — | — | 1 | 9.40 |
| CHEMBL1076603 | — | — | 1 | 9.40 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.30 |
| CHEMBL1076663 | — | — | 1 | 9.30 |
| CHEMBL1076632 | — | — | 1 | 9.22 |
| CHEMBL1076601 | — | — | 1 | 9.22 |
| CHEMBL1076613 | — | — | 1 | 9.15 |
| CHEMBL1076633 | — | — | 1 | 9.15 |
| CHEMBL1076662 | — | — | 1 | 9.15 |
| CHEMBL1076612 | — | — | 1 | 9.10 |
| CHEMBL1076631 | — | — | 1 | 8.42 |
| CHEMBL1076630 | — | — | 1 | 7.89 |
| CHEMBL1076664 | — | — | 1 | 7.50 |
| CHEMBL1076629 | — | — | 1 | 7.24 |
| CHEMBL1076661 | — | — | 1 | - |
| CHEMBL1076605 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1076604 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1076602 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1076603 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1076663 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1076632 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1076601 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1076613 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1076633 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1076662 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1076612 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL1076631 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1076630 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL1076664 | — | Ki | = | 31.6 | nM | 7.50 |
| CHEMBL1076629 | — | Ki | = | 58.2 | nM | 7.24 |
| CHEMBL1076661 | — | Ki | >= | 250.0 | nM | - |
| CHEMBL1076605 | — | Ki | >= | 250.0 | nM | - |