Assay Detail
Binding
CHEMBL649315
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In vitro binding affinity against Angiotensin II receptor, type 1 from rat liver membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.37 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406349 | — | — | 1 | 9.72 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.28 |
| CHEMBL411733 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406349 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL411733 | — | Ki | = | 750.0 | nM | 6.12 |