Angiotensin II receptor (AT-1) type-1 · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P29089. Use UniProt P29089 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P29089 as the stable identity anchor, then attach disease evidence before program review.
Type-1 angiotensin II receptor B
Review this target as Angiotensin II receptor (AT-1) type-1, mapped to UniProt P29089. ChEMBL maps the protein component as Type-1 angiotensin II receptor B. Sequence length is 359 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Angiotensin II receptor (AT-1) type-1 as ChEMBL target CHEMBL2094250, mapped to UniProt P29089. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Angiotensin II receptor (AT-1) type-1 is the right protein anchor across sources, using UniProt P29089 as the stable mapping.
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| Preferred Name | Angiotensin II receptor (AT-1) type-1 |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P29089 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Type-1 angiotensin II receptor B |
| UniProt Accession | P29089 |
| Component Type | Protein |
| Sequence Length | 359 aa |
Type-1 angiotensin II receptor B
Review this target as Angiotensin II receptor (AT-1) type-1, mapped to UniProt P29089. ChEMBL maps the protein component as Type-1 angiotensin II receptor B. Sequence length is 359 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL313598 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL87244 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL90618 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL315236 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL89032 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL431853 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL312937 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL314975 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL338101 | 10.15 | IC50 | 0.071 | Preclinical |
| CHEMBL84908 | 10.15 | IC50 | 0.07 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 31 | 312 | 8.0 |
| assay format | 24 | 418 | 8.0 |
| tissue-based format | 8 | 152 | 8.1 |
| protein format | 7 | 35 | 8.8 |
| cell-free format | 5 | 6 | 6.9 |
| microsome format | 3 | 29 | 7.8 |
| cell-based format | 2 | 4 | 8.2 |
| organism-based format | 1 | 21 | 9.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 43 | 6 | 7.2 |
| tissue-based format | 6 | 15 | 7.5 |
| assay format | 4 | 4 | 7.1 |