Assay Detail
Binding
CHEMBL647776
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Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A selective AT2 receptor ligand with a gamma-turn-like mimetic replacing the amino acid residues 4-5 of angiotensin II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.65 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.64 |
| CHEMBL404996 | — | — | 1 | 9.21 |
| CHEMBL268815 | — | — | 1 | 8.68 |
| CHEMBL414478 | — | — | 1 | 8.52 |
| CHEMBL1791259 | — | — | 2 | 7.21 |
| CHEMBL415394 | — | — | 1 | - |
| CHEMBL407801 | — | — | 1 | - |
| CHEMBL386257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL404996 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL268815 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL414478 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1791259 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL415394 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL407801 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1791259 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL386257 | — | Ki | > | 10000.0 | nM | - |