Assay Detail
Binding
CHEMBL909477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Ang2 from AT1 receptor in rat liver membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT1 and AT2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.32 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 10.00 |
| CHEMBL385706 | — | — | 1 | 7.83 |
| CHEMBL265613 | — | — | 1 | 5.78 |
| CHEMBL425077 | — | — | 1 | 5.68 |
| CHEMBL268815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL385706 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL265613 | — | Ki | = | 1668.0 | nM | 5.78 |
| CHEMBL425077 | — | Ki | = | 2108.0 | nM | 5.68 |
| CHEMBL268815 | — | Ki | > | 10000.0 | nM | - |