Compound Detail
CHEMBL425077
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CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O
Basic Information
| ChEMBL ID | CHEMBL425077 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQPFNGHGEBYHLU-GUZINXMVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
913.0
MW (Da)
1.23
ALogP
11
HBA
10
HBD
325.2
PSA (Ų)
0.04
QED
3
Ro5 Violations
21
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-2 angiotensin II receptor CHEMBL4607 | Ki | 7.28 | 7.28 | 53.1 | 1 |
| Angiotensin II receptor (AT-1) type-1 CHEMBL2094250 | Ki | 5.68 | 5.68 | 2108.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-2 angiotensin II receptor | Ki | = | 53.1 | nM | 7.28 | Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium | 17004728 |
| Angiotensin II receptor (AT-1) type-1 | Ki | = | 2108.0 | nM | 5.68 | Displacement of [125I]Ang2 from AT1 receptor in rat liver membrane | 17004728 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17004728 | 10.1021/jm051222g | Angiotensin II receptor (AT-1) type-1 | 1 |
| 17004728 | 10.1021/jm051222g | Type-2 angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine