Assay Detail
Binding
CHEMBL909478
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Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Uterus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT1 and AT2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.54 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.22 |
| CHEMBL268815 | — | — | 1 | 9.15 |
| CHEMBL385706 | — | — | 1 | 8.74 |
| CHEMBL265613 | — | — | 1 | 8.33 |
| CHEMBL425077 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL268815 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL385706 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL265613 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL425077 | — | Ki | = | 53.1 | nM | 7.28 |