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Compound Detail

CHEMBL265613

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CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O

Basic Information

ChEMBL ID CHEMBL265613
Phase Preclinical
Structure Type MOL
InChI Key WHZVHCDJQPSKEV-CANRTOTLSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

1050.2
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C52H67N13O11
MW 1050.19

Activity Summary

Ki 2 meas. best 8.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Type-2 angiotensin II receptor
CHEMBL4607
Ki 8.33 8.33 4.7 1
Angiotensin II receptor (AT-1) type-1
CHEMBL2094250
Ki 5.78 5.78 1668.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17004728 10.1021/jm051222g Angiotensin II receptor (AT-1) type-1 1
17004728 10.1021/jm051222g Type-2 angiotensin II receptor 1

Data from ChEMBL 36 via Core Engine