Assay Detail
Binding
CHEMBL915386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Ang2 from AT1 receptor in rat liver membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.55 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.30 |
| CHEMBL385998 | — | — | 1 | 5.80 |
| CHEMBL376286 | — | — | 1 | - |
| CHEMBL219840 | — | — | 1 | - |
| CHEMBL376869 | — | — | 1 | - |
| CHEMBL219839 | — | — | 1 | - |
| CHEMBL219838 | — | — | 1 | - |
| CHEMBL374751 | — | — | 1 | - |
| CHEMBL375335 | — | — | 1 | - |
| CHEMBL374726 | — | — | 1 | - |
| CHEMBL374725 | — | — | 1 | - |
| CHEMBL426885 | — | — | 1 | - |
| CHEMBL375366 | — | — | 1 | - |
| CHEMBL424755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL385998 | — | Ki | = | 1598.0 | nM | 5.80 |
| CHEMBL376286 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL219840 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL376869 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL219839 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL219838 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL374751 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL375335 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL374726 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL374725 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL426885 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL375366 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL424755 | — | Ki | > | 10000.0 | nM | - |