Assay Detail
Binding
CHEMBL648766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for angiotensin II receptor type 1 using [125I]- Ang II in rat liver membranes
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
A selective AT2 receptor ligand with a gamma-turn-like mimetic replacing the amino acid residues 4-5 of angiotensin II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.49 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.62 |
| CHEMBL404996 | — | — | 1 | 7.36 |
| CHEMBL415394 | — | — | 1 | - |
| CHEMBL268815 | — | — | 1 | - |
| CHEMBL407801 | — | — | 1 | - |
| CHEMBL1791259 | — | — | 2 | - |
| CHEMBL414478 | — | — | 1 | - |
| CHEMBL386257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL404996 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL415394 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL268815 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL407801 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1791259 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL414478 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1791259 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL386257 | — | Ki | > | 10000.0 | nM | - |