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Assay Detail

CHEMBL3768051

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Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Type-2 angiotensin II receptor (CHEMBL4607)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural determinants of subtype selectivity and functional activity of angiotensin II receptors.
Sallander J, Wallinder C, Hallberg A, Åqvist J, Gutiérrez-de-Terán H.
Bioorg Med Chem Lett (2016) 26 : 1355 -1359
PubMed 26810314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 9 8.82 9.85
IC50 3 8.77 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404594 1 9.85
CHEMBL408403 ANGIOTENSIN II 4.0 1 9.70
CHEMBL938 SARALASIN 4.0 1 9.42
CHEMBL189568 BULOXIBUTID 0.5 1 9.40
CHEMBL217673 1 9.15
CHEMBL289614 1 9.15
CHEMBL39959 1 8.38
CHEMBL3394207 1 7.91
CHEMBL2086892 1 7.75
CHEMBL34124 OLODANRIGAN 2.0 1 7.40
CHEMBL191 LOSARTAN 4.0 1 -
CHEMBL1016 CANDESARTAN 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404594 Ki = 0.14 nM 9.85
CHEMBL408403 ANGIOTENSIN II Ki = 0.2 nM 9.70
CHEMBL938 SARALASIN Ki = 0.38 nM 9.42
CHEMBL189568 BULOXIBUTID Ki = 0.4 nM 9.40
CHEMBL217673 Ki = 0.7 nM 9.15
CHEMBL289614 IC50 = 0.7 nM 9.15
CHEMBL39959 IC50 = 4.2 nM 8.38
CHEMBL3394207 Ki = 12.3 nM 7.91
CHEMBL2086892 Ki = 17.8 nM 7.75
CHEMBL34124 OLODANRIGAN Ki = 39.5 nM 7.40
CHEMBL191 LOSARTAN IC50 > 10000.0 nM -
CHEMBL1016 CANDESARTAN Ki > 10000.0 nM -