Assay Detail
Binding
CHEMBL883665
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Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.38 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216061 | — | — | 1 | 9.74 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.70 |
| CHEMBL3350599 | — | — | 1 | 9.15 |
| CHEMBL428986 | — | — | 1 | 8.73 |
| CHEMBL276163 | — | — | 1 | 8.01 |
| CHEMBL196316 | — | — | 1 | 8.00 |
| CHEMBL194864 | — | — | 1 | 7.38 |
| CHEMBL3350600 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216061 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3350599 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL428986 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL276163 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL196316 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL194864 | — | Ki | = | 41.3 | nM | 7.38 |
| CHEMBL3350600 | — | Ki | = | 463.7 | nM | 6.33 |