Assay Detail
Binding
CHEMBL829830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-Ang II from angiotensin II receptor type 1 in rat liver membranes
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.62 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.62 |
| CHEMBL414478 | — | — | 1 | - |
| CHEMBL386257 | — | — | 1 | - |
| CHEMBL265881 | — | — | 1 | - |
| CHEMBL409528 | — | — | 1 | - |
| CHEMBL406907 | — | — | 1 | - |
| CHEMBL371395 | — | — | 1 | - |
| CHEMBL1791308 | — | — | 2 | - |
| CHEMBL1791309 | — | — | 2 | - |
| CHEMBL268815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL414478 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL386257 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL265881 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL409528 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL406907 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL371395 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1791308 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1791309 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1791308 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL268815 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1791309 | — | Ki | > | 10000.0 | nM | - |