Assay Detail
Binding
CHEMBL915840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Uterus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.86 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.52 |
| CHEMBL424755 | — | — | 1 | 9.05 |
| CHEMBL376286 | — | — | 1 | 7.78 |
| CHEMBL219840 | — | — | 1 | 7.43 |
| CHEMBL219839 | — | — | 1 | 7.39 |
| CHEMBL426885 | — | — | 1 | 5.96 |
| CHEMBL376869 | — | — | 1 | - |
| CHEMBL219838 | — | — | 1 | - |
| CHEMBL374751 | — | — | 1 | - |
| CHEMBL375335 | — | — | 1 | - |
| CHEMBL374726 | — | — | 1 | - |
| CHEMBL374725 | — | — | 1 | - |
| CHEMBL385998 | — | — | 1 | - |
| CHEMBL375366 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL424755 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL376286 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL219840 | — | Ki | = | 37.5 | nM | 7.43 |
| CHEMBL219839 | — | Ki | = | 40.6 | nM | 7.39 |
| CHEMBL426885 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL376869 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL219838 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL374751 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL375335 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL374726 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL374725 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL385998 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL375366 | — | Ki | > | 10000.0 | nM | - |