Assay Detail
Binding
CHEMBL3789066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
14
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.54 | 9.62 |
| IC50 | 5 | 8.31 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 2 | 9.62 |
| CHEMBL3787243 | — | — | 2 | 9.15 |
| CHEMBL3786145 | — | — | 2 | 8.68 |
| CHEMBL3786986 | — | — | 1 | 8.55 |
| CHEMBL3787379 | — | — | 1 | 8.51 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 2 | 8.46 |
| CHEMBL3785563 | — | — | 2 | 8.05 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.92 |
| CHEMBL4299329 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL3787243 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL408403 | ANGIOTENSIN II | IC50 | = | 0.7244 | nM | 9.14 |
| CHEMBL3786145 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL3787243 | — | IC50 | = | 2.188 | nM | 8.66 |
| CHEMBL3786986 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL3787379 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL1016 | CANDESARTAN | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL3786145 | — | IC50 | = | 6.166 | nM | 8.21 |
| CHEMBL3785563 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1016 | CANDESARTAN | IC50 | = | 10.72 | nM | 7.97 |
| CHEMBL191 | LOSARTAN | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4299329 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3785563 | — | IC50 | = | 28.18 | nM | 7.55 |