Assay Detail
Binding
CHEMBL648961
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Binding affinity for rat angiotensin II receptor, type 1
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.64 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7550 | L-158809 | — | 1 | 9.40 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.40 |
| CHEMBL315104 | — | — | 1 | 9.10 |
| CHEMBL296725 | — | — | 1 | 9.00 |
| CHEMBL1069 | VALSARTAN | 4.0 | 1 | 8.72 |
| CHEMBL47382 | — | — | 1 | 8.40 |
| CHEMBL87327 | — | — | 1 | 8.38 |
| CHEMBL85595 | — | — | 1 | 8.25 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.17 |
| CHEMBL315022 | — | — | 1 | 8.17 |
| CHEMBL86247 | — | — | 1 | 8.16 |
| CHEMBL315021 | FORASARTAN | 2.0 | 1 | 8.16 |
| CHEMBL314315 | — | — | 1 | 8.11 |
| CHEMBL84573 | — | — | 1 | 8.05 |
| CHEMBL87842 | — | — | 1 | 8.00 |
| CHEMBL87779 | — | — | 1 | 7.96 |
| CHEMBL315387 | — | — | 1 | 7.92 |
| CHEMBL315165 | — | — | 1 | 7.89 |
| CHEMBL86562 | — | — | 1 | 7.89 |
| CHEMBL85405 | — | — | 1 | 7.89 |
| CHEMBL86437 | — | — | 1 | 7.77 |
| CHEMBL86346 | — | — | 1 | 7.75 |
| CHEMBL86436 | — | — | 1 | 7.54 |
| CHEMBL541212 | — | — | 1 | 7.48 |
| CHEMBL423861 | — | — | 1 | 7.39 |
| CHEMBL86655 | — | — | 1 | 7.28 |
| CHEMBL47459 | — | — | 1 | 7.22 |
| CHEMBL312889 | — | — | 1 | 7.18 |
| CHEMBL87884 | — | — | 1 | 7.13 |
| CHEMBL86344 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7550 | L-158809 | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL408403 | ANGIOTENSIN II | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL315104 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL296725 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1069 | VALSARTAN | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL47382 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL87327 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL85595 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL191 | LOSARTAN | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL315022 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL86247 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL315021 | FORASARTAN | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL314315 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL84573 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL87842 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL87779 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL315387 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL315165 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL86562 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL85405 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL86437 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL86346 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL86436 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL541212 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL423861 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL86655 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL47459 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL312889 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL87884 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL86344 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL83414 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL88067 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL410939 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL87411 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL437659 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL87655 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL314807 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL87694 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL83452 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL313718 | — | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL88081 | — | IC50 | = | 819.0 | nM | 6.09 |
| CHEMBL87997 | — | IC50 | > | 300.0 | nM | - |