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Assay Detail

CHEMBL3791117

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma counting
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type COS-7
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Type-1 angiotensin II receptor (CHEMBL227)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.
Keller M, Kuhn KK, Einsiedel J, Hübner H, Biselli S, Mollereau C, Wifling D, Svobodová J, Bernhardt G, Cabrele C, Vanderheyden PM, Gmeiner P, Buschauer A.
J Med Chem (2016) 59 : 1925 -1945
PubMed 26824643 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.80 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL408403 ANGIOTENSIN II 4.0 1 9.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL408403 ANGIOTENSIN II Ki = 0.16 nM 9.80