Assay Detail
Binding
CHEMBL647796
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Compound was evaluated in a radioligand binding assay to displace [125I]-Ang II from Angiotensin II receptor, type 1 in rat liver membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Bicyclic tripeptide mimetics with reverse turn inducing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.28 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.28 |
| CHEMBL268623 | — | — | 1 | - |
| CHEMBL415197 | — | — | 1 | - |
| CHEMBL264714 | — | — | 1 | - |
| CHEMBL405570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL268623 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL415197 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL264714 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL405570 | — | IC50 | >= | 10000.0 | nM | - |