Assay Detail
Functional
CHEMBL3789064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
12
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.88 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 2 | 9.31 |
| CHEMBL3787243 | — | — | 2 | 8.96 |
| CHEMBL3786145 | — | — | 2 | 8.85 |
| CHEMBL3786986 | — | — | 2 | 8.69 |
| CHEMBL3787379 | — | — | 2 | 8.63 |
| CHEMBL3785563 | — | — | 1 | - |
| CHEMBL4299329 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | EC50 | = | 0.4898 | nM | 9.31 |
| CHEMBL408403 | ANGIOTENSIN II | EC50 | = | 0.52 | nM | 9.28 |
| CHEMBL3787243 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3787243 | — | EC50 | = | 1.096 | nM | 8.96 |
| CHEMBL3786145 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3786145 | — | EC50 | = | 1.413 | nM | 8.85 |
| CHEMBL3786986 | — | EC50 | = | 2.042 | nM | 8.69 |
| CHEMBL3786986 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3787379 | — | EC50 | = | 2.344 | nM | 8.63 |
| CHEMBL3787379 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3785563 | — | EC50 | - | — | - | |
| CHEMBL4299329 | — | EC50 | - | — | - |