Compound Detail
CHEMBL1026
FENOLDOPAM MESYLATE 💊 Approved Drug
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💊 Approved Drug
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
20
Publications
10
Known Names
2
Indications
1
Mechanisms
Molecular Properties
305.8
MW (Da)
2.73
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1997 |
| Availability | Discontinued |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Dopamine D1 receptor agonist | AGONIST | D(1A) dopamine receptor | ✓ | ✓ |
Indications
Hypertension Acute Kidney Injury
Activity Summary
EC50 4 meas. best 7.32
IC50 2 meas. best 5.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | EC50 | 7.32 | 7.28 | 48.0 | 2 |
| Oryctolagus cuniculus CHEMBL374 | EC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Trace amine-associated receptor 1 CHEMBL5857 | EC50 | 5.57 | 5.57 | 2703.0 | 1 |
| Trace amine-associated receptor 1 CHEMBL5857 | IC50 | 5.09 | 5.09 | 8044.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.51 | 4.51 | 31000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | EC50 | = | 48.0 | nM | 7.32 | In vitro dose stimulating D-1 adenylate cyclase in rat caudate nuclei | 2878077 |
| Rattus norvegicus | EC50 | = | 57.0 | nM | 7.24 | Concentration necessary to cause 50% increase in cAMP formation(by adenylate cyc... | 2871192 |
| Oryctolagus cuniculus | EC50 | = | 1000.0 | nM | 6.0 | Inhibition of the constrictor response to electrical stimulation in rabbit ear a... | 2871192 |
| Trace amine-associated receptor 1 | EC50 | = | 2703.0 | nM | 5.57 | PubChem BioAssay. Fluorescence-based cell-based high throughput dose response as... | - |
| Trace amine-associated receptor 1 | IC50 | = | 8044.0 | nM | 5.09 | PubChem BioAssay. Counterscreen for agonists of the human trace amine associated... | - |
| Unchecked | IC50 | = | 31000.0 | nM | 4.51 | Inhibition of biotinylated 5-(4-((Z)-3-Carboxy-3-hydroxyacryloyl)-4-(4-chloroben... | 32883638 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2878077 | 10.1021/jm00161a029 | Canis familiaris | 5 |
| 7069713 | 10.1021/jm00346a005 | Canis familiaris | 4 |
| 7069713 | 10.1021/jm00346a005 | Unchecked | 3 |
| 2878077 | 10.1021/jm00161a029 | Rattus norvegicus | 3 |
| 7069713 | 10.1021/jm00346a005 | Rattus norvegicus | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 23956101 | 10.1093/toxsci/kft176 | Bile salt export pump | 1 |
| 23956101 | 10.1093/toxsci/kft176 | ATP-binding cassette sub-family C member 2 | 1 |
| 23956101 | 10.1093/toxsci/kft176 | ATP-binding cassette sub-family C member 3 | 1 |
| 23956101 | 10.1093/toxsci/kft176 | ATP-binding cassette sub-family C member 4 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 2871192 | 10.1021/jm00155a024 | Rattus norvegicus | 1 |
| - | 10.6019/CHEMBL4513141 | Candida albicans | 1 |
| - | 10.6019/CHEMBL4513141 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4513141 | Escherichia coli | 1 |
| - | 10.6019/CHEMBL4513141 | Klebsiella pneumoniae | 1 |
| - | 10.6019/CHEMBL4513141 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4513141 | Acinetobacter baumannii | 1 |
Data from ChEMBL 36 via Core Engine