Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL376 Target Snapshot

Rattus norvegicus · ORGANISM · Rattus norvegicus

84,789Compounds
104,649Assays
152Approved Drugs
9,657.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Rattus norvegicus as ChEMBL target CHEMBL376. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Rattus norvegicus
ORGANISM · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL376
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Rattus norvegicus still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRattus norvegicus
UniProt AccessionN/A

Rattus norvegicus

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Rattus norvegicus.

Review nameRattus norvegicus
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

152
Approved
45
Phase III
110
Phase II
12
Phase I
Assay Mix

Activity Type Distribution

IC505,831.0
KI433.0
EC502,308.0
KD1,085.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL265538 11.0 Kd 0.01 Preclinical
CHEMBL1121 10.85 EC50 0.014 Approved
CHEMBL384341 10.85 Kd 0.01413 Preclinical
CHEMBL8946 10.85 Ki 0.014 Clinical
CHEMBL428299 10.8 Kd 0.01585 Preclinical
CHEMBL409219 10.8 Kd 0.01585 Preclinical
CHEMBL85340 10.77 EC50 0.01698 Preclinical
CHEMBL216589 10.75 Kd 0.01778 Preclinical
CHEMBL3350238 10.74 IC50 0.018 Preclinical
CHEMBL305699 10.7 Kd 0.02 Preclinical
Distribution

pChEMBL Value Distribution

847
5.0
865
5.5
895
6.0
827
6.5
699
7.0
721
7.5
516
8.0
296
8.5
122
9.0
60
9.5
pChEMBL
Approved Drugs

Approved Drugs

ETRASIMOD
CHEMBL3358920
Approved 2023
LENIOLISIB
CHEMBL3643413
Approved 2023
MAVACAMTEN
CHEMBL4297517
Approved 2022
ERTUGLIFLOZIN
CHEMBL1770248
Approved 2017
COCAINE
CHEMBL370805
Approved 2017
PASIREOTIDE
CHEMBL3349607
Approved 2012
BOSUTINIB
CHEMBL288441
Approved 2012
CAPSAICIN
CHEMBL294199
Approved 2009
ICATIBANT
CHEMBL2028850
Approved 2008
MELATONIN
CHEMBL45
Approved 2007
RIMONABANT
CHEMBL111
Approved 2006
SITAXENTAN
CHEMBL282724
Approved 2006
RAMELTEON
CHEMBL1218
Approved 2005
MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
DULOXETINE
CHEMBL1175
Approved 2004
ILOPROST
CHEMBL494
Approved 2003
ALFUZOSIN
CHEMBL709
Approved 2003
TADALAFIL
CHEMBL779
Approved 2002
ATOMOXETINE HYDROCHLORIDE
CHEMBL1702
Approved 2002
ATOMOXETINE
CHEMBL641
Approved 2002
DEXMETHYLPHENIDATE
CHEMBL827
Approved 2001
APOMORPHINE
CHEMBL53
Approved 2001
ATOSIBAN
CHEMBL382301
Approved 2000
LEFLUNOMIDE
CHEMBL960
Approved 1998
FENOLDOPAM MESYLATE
CHEMBL1026
Approved 1997
TAMSULOSIN
CHEMBL836
Approved 1997
FENOLDOPAM
CHEMBL588
Approved 1997
ANAGRELIDE
CHEMBL760
Approved 1997
EPOPROSTENOL
CHEMBL1139
Approved 1995
LOSARTAN
CHEMBL191
Approved 1995
NISOLDIPINE
CHEMBL1726
Approved 1995
ALENDRONIC ACID
CHEMBL870
Approved 1995
CISAPRIDE
CHEMBL1729
Approved 1993
FLUVASTATIN SODIUM
CHEMBL2218894
Approved 1993
RISPERIDONE
CHEMBL85
Approved 1993
AMLODIPINE
CHEMBL1491
Approved 1992
PAROXETINE
CHEMBL490
Approved 1992
ONDANSETRON
CHEMBL46
Approved 1991
SERTRALINE
CHEMBL809
Approved 1991
PRAVASTATIN SODIUM
CHEMBL690
Approved 1991
PODOFILOX
CHEMBL61
Approved 1990
DOXAZOSIN
CHEMBL707
Approved 1990
TOLRESTAT
CHEMBL436
Approved 1989
PINACIDIL ANHYDROUS
CHEMBL1159
Approved 1989
CLOMIPRAMINE
CHEMBL415
Approved 1989
NICARDIPINE
CHEMBL1484
Approved 1988
PERGOLIDE MESYLATE
CHEMBL1275
Approved 1988
NIMODIPINE
CHEMBL1428
Approved 1988
FLUOXETINE
CHEMBL41
Approved 1987
TERAZOSIN
CHEMBL611
Approved 1987
Source · ChEMBL 36 via Core Engine