Compound Detail
CHEMBL428299
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CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCNC(=O)c1cccnc1)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1ccc(Cl)cc1
Basic Information
| ChEMBL ID | CHEMBL428299 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AJOVQXQOCNTOQK-LXQKLVQBSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1261.9
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 10.8
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | Kd | 10.8 | 10.8 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | Kd | = | 0.01585 | nM | 10.8 | In vitro antagonistic potency against release of luteinizing hormone (LH) from c... | 7510341 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7510341 | 10.1021/jm00031a021 | Gonadotropin-releasing hormone receptor | 1 |
| 7510341 | 10.1021/jm00031a021 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine