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Assay Detail

CHEMBL802867

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Functional
In vitro antagonistic potency against release of luteinizing hormone (LH) from cultured rat pituitary cells.
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Cell Type Pituitary gland cell
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376) ↗
Type ORGANISM
Organism Rattus norvegicus

Publication

In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone.
Haviv F, Fitzpatrick TD, Nichols CJ, Bush EN, Diaz G, Bammert G, Nguyen AT, Johnson ES, Knittle J, Greer J.
J Med Chem (1994) 37 : 701 -705
PubMed 7510341 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 50 9.10 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL265538 — — 1 11.00
CHEMBL384341 — — 1 10.85
CHEMBL428299 — — 1 10.80
CHEMBL216589 — — 1 10.75
CHEMBL2371296 — — 1 10.50
CHEMBL266475 — — 1 10.46
CHEMBL429365 — — 1 10.45
CHEMBL2369141 — — 1 10.41
CHEMBL2369140 — — 1 10.08
CHEMBL406887 — — 1 10.06
CHEMBL405993 — — 1 10.02
CHEMBL415562 — — 1 9.94
CHEMBL428138 — — 1 9.90
CHEMBL428093 — — 1 9.78
CHEMBL413660 — — 1 9.66
CHEMBL405994 — — 1 9.35
CHEMBL437632 — — 1 9.23
CHEMBL2369142 — — 1 9.07
CHEMBL268620 — — 1 9.07
CHEMBL405812 — — 1 9.05
CHEMBL263315 — — 1 9.02
CHEMBL278704 — — 1 8.62
CHEMBL264989 — — 1 8.62
CHEMBL406447 — — 1 8.58
CHEMBL262977 — — 1 8.26
CHEMBL264728 — — 1 8.26
CHEMBL408026 — — 1 8.11
CHEMBL266032 — — 1 8.02
CHEMBL2371292 — — 1 7.90
CHEMBL415643 — — 1 7.81

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL265538 — Kd = 0.01 nM 11.00
CHEMBL384341 — Kd = 0.01413 nM 10.85
CHEMBL428299 — Kd = 0.01585 nM 10.80
CHEMBL216589 — Kd = 0.01778 nM 10.75
CHEMBL2371296 — Kd = 0.03162 nM 10.50
CHEMBL266475 — Kd = 0.03467 nM 10.46
CHEMBL429365 — Kd = 0.03548 nM 10.45
CHEMBL2369141 — Kd = 0.0389 nM 10.41
CHEMBL2369140 — Kd = 0.08318 nM 10.08
CHEMBL406887 — Kd = 0.0871 nM 10.06
CHEMBL405993 — Kd = 0.0955 nM 10.02
CHEMBL415562 — Kd = 0.1148 nM 9.94
CHEMBL428138 — Kd = 0.1259 nM 9.90
CHEMBL428093 — Kd = 0.166 nM 9.78
CHEMBL413660 — Kd = 0.2188 nM 9.66
CHEMBL405994 — Kd = 0.4467 nM 9.35
CHEMBL437632 — Kd = 0.5888 nM 9.23
CHEMBL2369142 — Kd = 0.8511 nM 9.07
CHEMBL268620 — Kd = 0.8511 nM 9.07
CHEMBL405812 — Kd = 0.8913 nM 9.05
CHEMBL263315 — Kd = 0.955 nM 9.02
CHEMBL278704 — Kd = 2.399 nM 8.62
CHEMBL264989 — Kd = 2.399 nM 8.62
CHEMBL406447 — Kd = 2.63 nM 8.58
CHEMBL264728 — Kd = 5.495 nM 8.26
CHEMBL262977 — Kd = 5.495 nM 8.26
CHEMBL408026 — Kd = 7.762 nM 8.11
CHEMBL266032 — Kd = 9.55 nM 8.02
CHEMBL2371292 — Kd = 12.59 nM 7.90
CHEMBL415643 — Kd = 15.49 nM 7.81
CHEMBL264255 — Kd = 17.78 nM 7.75
CHEMBL427603 — Kd = 20.89 nM 7.68
CHEMBL407073 — Kd = 20.89 nM 7.68
CHEMBL439292 — Kd = 21.38 nM 7.67
CHEMBL383936 — Kd = 22.91 nM 7.64
CHEMBL217013 — Kd = 41.69 nM 7.38
CHEMBL406886 — Kd = 44.67 nM 7.35
CHEMBL217175 — Kd = 0.005623 nM -
CHEMBL412751 — Kd = 0.006918 nM -
CHEMBL267709 — Kd = 0.008913 nM -
CHEMBL262235 — Kd = 0.007079 nM -
CHEMBL267843 — Kd = 0.00631 nM -
CHEMBL408861 — Kd = 0.005012 nM -
CHEMBL438195 — Kd = 0.007413 nM -
CHEMBL2371295 — Kd = 0.008913 nM -
CHEMBL383952 — Kd = 0.003981 nM -
CHEMBL445681 — Kd = 0.007079 nM -
CHEMBL413393 — Kd = 0.00871 nM -
CHEMBL268173 — Kd = 0.005888 nM -
CHEMBL439134 — Kd = 0.003715 nM -