Compound Detail
CHEMBL2218894
FLUVASTATIN SODIUM 💊 Approved Drug
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💊 Approved Drug
CC(C)n1c(/C=C/C(O)CC(O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21.[Na+]
Basic Information
| ChEMBL ID | CHEMBL2218894 |
| Name | FLUVASTATIN SODIUM |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | ZGGHKIMDNBDHJB-CALJPSDSSA-M |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL2220442 |
| Active Moiety | CHEMBL2220442 |
5
Targets
21
Activities
1
Assay Types
0
PK Parameters
13
Publications
21
Known Names
3
Indications
1
Mechanisms
Molecular Properties
411.5
MW (Da)
4.63
ALogP
4
HBA
3
HBD
82.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1993 |
| Availability | Prescription |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| HMG-CoA reductase inhibitor | INHIBITOR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | ✓ | ✓ |
Indications
Hypercholesterolemia Hyperlipoproteinemia Type II Breast Neoplasms
Activity Summary
IC50 21 meas. best 8.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase CHEMBL3247 | IC50 | 8.6 | 7.3425 | 2.5 | 4 |
| Rattus norvegicus CHEMBL376 | IC50 | 8.4 | 7.2633 | 4.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 7.4 | 5.7514 | 39.9 | 7 |
| HepG2 CHEMBL395 | IC50 | 7.1 | 7.1 | 79.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.06 | 4.0425 | 87100.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9836611 | 10.1021/jm9810102 | No relevant target | 8 |
| 21447733 | 10.1124/dmd.111.038075 | ADMET | 8 |
| 17502414 | 10.1128/aac.01330-06 | Plasmodium falciparum | 6 |
| 1992149 | 10.1021/jm00105a071 | Rattus norvegicus | 3 |
| 1992149 | 10.1021/jm00105a071 | NON-PROTEIN TARGET | 2 |
| 9836611 | 10.1021/jm9810102 | Homo sapiens | 1 |
| 8246237 | 10.1021/jm00075a024 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1 |
| 8246237 | 10.1021/jm00075a024 | HepG2 | 1 |
| 1992149 | 10.1021/jm00105a071 | No relevant target | 1 |
| 1992149 | 10.1021/jm00105a071 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1 |
| 1656041 | 10.1021/jm00114a004 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1 |
| 17851082 | 10.1016/j.bmc.2007.08.044 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine