Assay Detail
Binding
CHEMBL691939
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit microsomal preparation of HMG-CoA reductase in rat liver.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.71 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368094 | — | — | 1 | 8.70 |
| CHEMBL2367472 | — | — | 1 | 8.18 |
| CHEMBL2367478 | — | — | 1 | 8.14 |
| CHEMBL3349878 | — | — | 1 | 8.12 |
| CHEMBL2368089 | — | — | 1 | 8.11 |
| CHEMBL2368088 | — | — | 1 | 8.03 |
| CHEMBL2367477 | — | — | 1 | 8.00 |
| CHEMBL11804 | — | — | 1 | 7.89 |
| CHEMBL3349881 | — | — | 1 | 7.89 |
| CHEMBL3349880 | — | — | 1 | 7.58 |
| CHEMBL2218894 | FLUVASTATIN SODIUM | 4.0 | 1 | 7.50 |
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | 7.40 |
| CHEMBL3349882 | — | — | 1 | 7.00 |
| CHEMBL3349879 | — | — | 1 | 6.85 |
| CHEMBL2368093 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368094 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2367472 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL2367478 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3349878 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL2368089 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL2368088 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2367477 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL11804 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3349881 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3349880 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2218894 | FLUVASTATIN SODIUM | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3349882 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3349879 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL2368093 | — | IC50 | = | 480.0 | nM | 6.32 |