Assay Detail
Binding
CHEMBL924005
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Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 mins
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and HMG CoA reductase inhibition of 4-thiophenyl quinolines as potential hypocholesterolemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.88 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239664 | — | — | 1 | 5.49 |
| CHEMBL239881 | — | — | 1 | 5.44 |
| CHEMBL239241 | — | — | 1 | 5.36 |
| CHEMBL239665 | — | — | 1 | 5.36 |
| CHEMBL391280 | — | — | 1 | 5.10 |
| CHEMBL1744447 | ROSUVASTATIN CALCIUM | 4.0 | 1 | 5.04 |
| CHEMBL239448 | — | — | 1 | 5.03 |
| CHEMBL1237061 | PITAVASTATIN CALCIUM | 4.0 | 1 | 4.98 |
| CHEMBL428560 | — | — | 1 | 4.97 |
| CHEMBL239450 | — | — | 1 | 4.97 |
| CHEMBL394156 | — | — | 1 | 4.92 |
| CHEMBL239242 | — | — | 1 | 4.90 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | 4.0 | 1 | 4.88 |
| CHEMBL269299 | — | — | 1 | 4.85 |
| CHEMBL239240 | — | — | 1 | 4.81 |
| CHEMBL391080 | — | — | 1 | 4.80 |
| CHEMBL394172 | — | — | 1 | 4.73 |
| CHEMBL2218894 | FLUVASTATIN SODIUM | 4.0 | 1 | 4.67 |
| CHEMBL239449 | — | — | 1 | 4.66 |
| CHEMBL239239 | — | — | 1 | 4.49 |
| CHEMBL239666 | — | — | 1 | 4.41 |
| CHEMBL392336 | — | — | 1 | 4.30 |
| CHEMBL269527 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239664 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL239881 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL239241 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL239665 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL391280 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL1744447 | ROSUVASTATIN CALCIUM | IC50 | = | 9030.0 | nM | 5.04 |
| CHEMBL239448 | — | IC50 | = | 9240.0 | nM | 5.03 |
| CHEMBL1237061 | PITAVASTATIN CALCIUM | IC50 | = | 10550.0 | nM | 4.98 |
| CHEMBL428560 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL239450 | — | IC50 | = | 10670.0 | nM | 4.97 |
| CHEMBL394156 | — | IC50 | = | 11940.0 | nM | 4.92 |
| CHEMBL239242 | — | IC50 | = | 12650.0 | nM | 4.90 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | IC50 | = | 13220.0 | nM | 4.88 |
| CHEMBL269299 | — | IC50 | = | 14150.0 | nM | 4.85 |
| CHEMBL239240 | — | IC50 | = | 15370.0 | nM | 4.81 |
| CHEMBL391080 | — | IC50 | = | 15750.0 | nM | 4.80 |
| CHEMBL394172 | — | IC50 | = | 18560.0 | nM | 4.73 |
| CHEMBL2218894 | FLUVASTATIN SODIUM | IC50 | = | 21210.0 | nM | 4.67 |
| CHEMBL239449 | — | IC50 | = | 22050.0 | nM | 4.66 |
| CHEMBL239239 | — | IC50 | = | 32550.0 | nM | 4.49 |
| CHEMBL239666 | — | IC50 | = | 38930.0 | nM | 4.41 |
| CHEMBL392336 | — | IC50 | = | 49670.0 | nM | 4.30 |
| CHEMBL269527 | — | IC50 | = | 74550.0 | nM | 4.13 |