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Assay Detail

CHEMBL779601

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Incorporation of [14C]- acetate into sterols measured in rat spleen.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Spleen
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.
Roth BD, Bocan TM, Blankley CJ, Chucholowski AW, Creger PL, Creswell MW, Ferguson E, Newton RS, O'Brien P, Picard JA.
J Med Chem (1991) 34 : 463 -466
PubMed 1992149 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.11 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3349881 1 8.30
CHEMBL2367478 1 7.92
CHEMBL2367472 1 7.70
CHEMBL2367477 1 7.54
CHEMBL3349878 1 7.54
CHEMBL2368094 1 7.11
CHEMBL2368093 1 7.04
CHEMBL3349879 1 6.97
CHEMBL3349880 1 6.85
CHEMBL690 PRAVASTATIN SODIUM 4.0 1 6.64
CHEMBL2218894 FLUVASTATIN SODIUM 4.0 1 6.54
CHEMBL3349882 1 6.43
CHEMBL11804 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3349881 IC50 = 5.0 nM 8.30
CHEMBL2367478 IC50 = 12.0 nM 7.92
CHEMBL2367472 IC50 = 20.0 nM 7.70
CHEMBL2367477 IC50 = 29.0 nM 7.54
CHEMBL3349878 IC50 = 29.0 nM 7.54
CHEMBL2368094 IC50 = 77.0 nM 7.11
CHEMBL2368093 IC50 = 92.0 nM 7.04
CHEMBL3349879 IC50 = 108.0 nM 6.97
CHEMBL3349880 IC50 = 140.0 nM 6.85
CHEMBL690 PRAVASTATIN SODIUM IC50 = 228.0 nM 6.64
CHEMBL2218894 FLUVASTATIN SODIUM IC50 = 292.0 nM 6.54
CHEMBL3349882 IC50 = 375.0 nM 6.43
CHEMBL11804 IC50 = 1579.0 nM 5.80