Assay Detail
Binding
CHEMBL691948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of solubilized HMG-CoA reductase in rat liver.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.30 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2367823 | — | — | 1 | 9.00 |
| CHEMBL2218894 | FLUVASTATIN SODIUM | 4.0 | 1 | 8.60 |
| CHEMBL102091 | — | — | 1 | 8.52 |
| CHEMBL2367826 | — | — | 1 | 8.52 |
| CHEMBL2367819 | — | — | 1 | 8.52 |
| CHEMBL2367825 | — | — | 1 | 8.35 |
| CHEMBL101203 | — | — | 1 | 7.46 |
| CHEMBL2367827 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2367823 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2218894 | FLUVASTATIN SODIUM | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL102091 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2367826 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2367819 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2367825 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL101203 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2367827 | — | IC50 | = | 38.0 | nM | 7.42 |