Assay Detail

CHEMBL686029

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Functional

Tested for ability to inhibit incorporation of [14C]acetate into cholesterol in cultured human hepatoma (HEP-G2) cells; 0.053-0.12

ChEMBL ↗

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Target

HepG2 (CHEMBL395) ↗

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Primary target HepG2

CHEMBL395

Anchored from Assay target.

Protein identity HepG2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HepG2
Confidence	1 — Organism
Curated By	Intermediate

Target

HepG2 (CHEMBL395) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts.

Connolly PJ, Westin CD, Loughney DA, Minor LK.
J Med Chem (1993) 36 : 3674 -3685
PubMed 8246237 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.10	7.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2218894	FLUVASTATIN SODIUM	4.0	1	7.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2218894	FLUVASTATIN SODIUM	IC50	=	79.0	nM	7.10