Assay Detail
Functional
CHEMBL779600
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Incorporation of [14C]- acetate into sterols measured in rat liver.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.60 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2367472 | — | — | 1 | 8.00 |
| CHEMBL2367477 | — | — | 1 | 7.77 |
| CHEMBL3349881 | — | — | 1 | 7.55 |
| CHEMBL2367478 | — | — | 1 | 7.47 |
| CHEMBL3349878 | — | — | 1 | 7.41 |
| CHEMBL2368089 | — | — | 1 | 7.15 |
| CHEMBL11804 | — | — | 1 | 6.97 |
| CHEMBL2218894 | FLUVASTATIN SODIUM | 4.0 | 1 | 6.85 |
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | 6.85 |
| CHEMBL3349880 | — | — | 1 | 5.56 |
| CHEMBL3349879 | — | — | 1 | 5.29 |
| CHEMBL3349882 | — | — | 1 | 5.22 |
| CHEMBL2368093 | — | — | 1 | 5.20 |
| CHEMBL2368094 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2367472 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2367477 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3349881 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2367478 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3349878 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2368089 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL11804 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL2218894 | FLUVASTATIN SODIUM | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3349880 | — | IC50 | = | 2726.0 | nM | 5.56 |
| CHEMBL3349879 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL3349882 | — | IC50 | = | 6037.0 | nM | 5.22 |
| CHEMBL2368093 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL2368094 | — | IC50 | = | 8070.0 | nM | 5.09 |