Assay Detail
Functional
CHEMBL781000
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration necessary to cause 50% increase in cAMP formation(by adenylate cyclase) relative to the maximum increase caused by the compound
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dopamine receptor agonists: 3-allyl-6-chloro-2,3,4,5-tetrahydro- 1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol and a series of related 3-benzazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.80 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788241 | — | — | 1 | 8.05 |
| CHEMBL130795 | — | — | 1 | 7.82 |
| CHEMBL1026 | FENOLDOPAM MESYLATE | 4.0 | 1 | 7.24 |
| CHEMBL162619 | — | — | 1 | 6.90 |
| CHEMBL163149 | — | — | 1 | 6.26 |
| CHEMBL164053 | — | — | 1 | 6.19 |
| CHEMBL540856 | — | — | 1 | 6.00 |
| CHEMBL537160 | — | — | 1 | 5.96 |
| CHEMBL542407 | — | — | 1 | - |
| CHEMBL2093047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788241 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL130795 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1026 | FENOLDOPAM MESYLATE | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL162619 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL163149 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL164053 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL540856 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL537160 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL542407 | — | EC50 | ~ | 10000.0 | nM | - |
| CHEMBL2093047 | — | EC50 | > | 10000.0 | nM | - |