Assay Detail
Functional
CHEMBL840884
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In vitro dose stimulating D-1 adenylate cyclase in rat caudate nuclei
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: halogen and methyl analogues of fenoldopam.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.54 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545230 | — | — | 1 | 7.40 |
| CHEMBL553147 | — | — | 1 | 7.35 |
| CHEMBL1026 | FENOLDOPAM MESYLATE | 4.0 | 1 | 7.32 |
| CHEMBL553503 | — | — | 1 | 7.19 |
| CHEMBL541559 | — | — | 1 | 7.00 |
| CHEMBL545464 | — | — | 1 | 7.00 |
| CHEMBL553578 | — | — | 1 | 6.82 |
| CHEMBL553305 | — | — | 1 | 6.70 |
| CHEMBL555500 | — | — | 1 | 6.70 |
| CHEMBL542652 | — | — | 1 | 5.90 |
| CHEMBL545229 | — | — | 1 | 5.58 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.46 |
| CHEMBL542407 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545230 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL553147 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1026 | FENOLDOPAM MESYLATE | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL553503 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL541559 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL545464 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL553578 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL553305 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL555500 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL542652 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL545229 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL59 | DOPAMINE | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL542407 | — | EC50 | = | 22000.0 | nM | 4.66 |