Assay Detail
Binding
CHEMBL4710189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of biotinylated 5-(4-((Z)-3-Carboxy-3-hydroxyacryloyl)-4-(4-chlorobenzyl)piperidine-1-carbonyl)-2-((13,35-dioxo-39-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)-3,6,9,16,19,22,25,28,31-nonaoxa-12,34-diazanonatriacontyl)oxy)benzoic acid binding to Influenza A virus (A/California/07/2009(H1N1)) N-terminal GST-tagged polymerase acidic subunit N-terminal domain expressed in Escherichia coli BL21 (DE3) RIL cells measured after 120 mins by Alphascreen assay
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/California/07/2009(H1N1)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 5.70 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | 2.0 | 1 | 7.62 |
| CHEMBL463590 | — | — | 1 | 7.58 |
| CHEMBL520866 | ORIENTIN | — | 1 | 7.37 |
| CHEMBL4752086 | — | — | 1 | 7.17 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 7.14 |
| CHEMBL247484 | TRICETIN | — | 1 | 6.80 |
| CHEMBL4778564 | — | — | 1 | 6.70 |
| CHEMBL4779818 | — | — | 1 | 6.54 |
| CHEMBL1544492 | — | — | 1 | 6.37 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.17 |
| CHEMBL164 | MYRICETIN | — | 1 | 6.12 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.06 |
| CHEMBL172350 | EUPAFOLIN | — | 1 | 6.03 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 6.02 |
| CHEMBL243677 | — | — | 1 | 5.89 |
| CHEMBL68810 | THUNBERGINOL A | — | 1 | 5.85 |
| CHEMBL66953 | PURPUROGALLIN | — | 1 | 5.82 |
| CHEMBL129964 | — | — | 1 | 5.77 |
| CHEMBL522983 | — | — | 1 | 5.75 |
| CHEMBL2074901 | — | — | 1 | 5.75 |
| CHEMBL487417 | VITEXIN | — | 1 | 5.72 |
| CHEMBL222556 | — | — | 1 | 5.62 |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | 5.48 |
| CHEMBL28626 | MORIN | — | 1 | 5.05 |
| CHEMBL4763188 | — | — | 1 | 5.01 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 4.89 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.80 |
| CHEMBL4799699 | — | — | 1 | 4.77 |
| CHEMBL464507 | GUAJAVERIN | — | 1 | 4.77 |
| CHEMBL8996 | ERIODICTYOL | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL463590 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL520866 | ORIENTIN | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4752086 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL247484 | TRICETIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4778564 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4779818 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1544492 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL50 | QUERCETIN | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL164 | MYRICETIN | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL172350 | EUPAFOLIN | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL31574 | FISETIN | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL243677 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL68810 | THUNBERGINOL A | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL66953 | PURPUROGALLIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL129964 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL522983 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2074901 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL487417 | VITEXIN | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL222556 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL28626 | MORIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4763188 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4799699 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL464507 | GUAJAVERIN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL8996 | ERIODICTYOL | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL15193 | LAPACHOL | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3348861 | AMPELOPSIN | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL140 | CURCUMIN | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1026 | FENOLDOPAM MESYLATE | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL233929 | GALUTEOLIN | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL66 | (+)-TAXIFOLIN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL502242 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL457821 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5 | NALIDIXIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL98745 | NARCICLASINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL28 | APIGENIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL239559 | ISOORIENTIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL131770 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL128748 | DIMETHYLCURCUMIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL90568 | DIOSMETIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL19032 | PENTAMETHYLQUERCETIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL77966 | RETUSIN | IC50 | > | 50000.0 | nM | - |