Compound Detail
CHEMBL5
NALIDIXIC ACID 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL5 |
| Name | NALIDIXIC ACID |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | MHWLWQUZZRMNGJ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
4
Targets
23
Activities
1
Assay Types
4
PK Parameters
20
Publications
15
Known Names
2
Indications
1
Mechanisms
Molecular Properties
232.2
MW (Da)
1.42
ALogP
4
HBA
1
HBD
72.2
PSA (Ų)
0.85
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1964 |
| Availability | Discontinued |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial DNA gyrase inhibitor | INHIBITOR | Bacterial DNA gyrase | ✓ | ✓ |
Indications
Bacterial Infections Osteomyelitis
ATC Classification
J01MB02
nalidixic acid
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
IC50 23 meas. best 4.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Pyruvate kinase PKM CHEMBL1075189 | IC50 | 4.28 | 4.28 | 53000.0 | 3 |
| ATP-binding cassette sub-family C member 4 CHEMBL1743128 | IC50 | 4.24 | 4.24 | 57500.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.22 | 4.14 | 60380.0 | 3 |
| DNA gyrase CHEMBL2094139 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.46 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 4.0 | mL.min-1.g-1 | Homo sapiens |
| F | 60.0 | % | Eutheria |
| T1/2 | 1.5 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine