Assay Detail
Binding
CHEMBL5223207
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Inhibition of PKM2 (unknown origin)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.52 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.30 |
| CHEMBL3609603 | — | — | 1 | 6.19 |
| CHEMBL126142 | — | — | 1 | 6.07 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 6.05 |
| CHEMBL28 | APIGENIN | — | 1 | 6.00 |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | 5.94 |
| CHEMBL80941 | — | — | 1 | 5.88 |
| CHEMBL15193 | LAPACHOL | — | 1 | 5.85 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.85 |
| CHEMBL4877010 | — | — | 1 | 5.70 |
| CHEMBL4128703 | — | — | 1 | 5.53 |
| CHEMBL214344 | — | — | 1 | 5.00 |
| CHEMBL32749 | FERULATE | -1.0 | 1 | 4.94 |
| CHEMBL1414 | SYRINGIC ACID | — | 1 | 4.86 |
| CHEMBL3695457 | — | — | 1 | 4.70 |
| CHEMBL15870 | INDOPROFEN | 4.0 | 1 | 4.68 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.48 |
| CHEMBL5 | NALIDIXIC ACID | 4.0 | 1 | 4.28 |
| CHEMBL477197 | HEMATOXYLIN | — | 1 | - |
| CHEMBL5288302 | — | — | 1 | - |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | - |
| CHEMBL142652 | PICEID | 2.0 | 1 | - |
| CHEMBL25080 | DL-PHENYLALANINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3609603 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL126142 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL31574 | FISETIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL28 | APIGENIN | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL66 | (+)-TAXIFOLIN | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL80941 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL15193 | LAPACHOL | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4877010 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4128703 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL214344 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL32749 | FERULATE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1414 | SYRINGIC ACID | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3695457 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL15870 | INDOPROFEN | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL265502 | SURAMIN | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL5 | NALIDIXIC ACID | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL477197 | HEMATOXYLIN | IC50 | = | 340000.0 | nM | - |
| CHEMBL5288302 | — | IC50 | - | — | - | |
| CHEMBL187266 | TANSHINONE IIA | IC50 | = | 1920000.0 | nM | - |
| CHEMBL142652 | PICEID | IC50 | = | 128000.0 | nM | - |
| CHEMBL25080 | DL-PHENYLALANINE | IC50 | = | 240000.0 | nM | - |