Assay Detail
Binding
CHEMBL5531336
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Inhibition of PKM2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.50 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.30 |
| CHEMBL4877010 | — | — | 1 | 5.70 |
| CHEMBL15870 | INDOPROFEN | 4.0 | 1 | 4.70 |
| CHEMBL5 | NALIDIXIC ACID | 4.0 | 1 | 4.28 |
| CHEMBL142652 | PICEID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4877010 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL15870 | INDOPROFEN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5 | NALIDIXIC ACID | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL142652 | PICEID | IC50 | = | 128000.0 | nM | - |