Assay Detail
Functional
CHEMBL770659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to relax the electrically stimulated rabbit ear artery was determined
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzothiazol-2-one 7-ethylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.62 | 10.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17231 | — | — | 1 | 10.55 |
| CHEMBL587 | SKF-89124A | — | 1 | 8.74 |
| CHEMBL17550 | — | — | 1 | 8.22 |
| CHEMBL279106 | — | — | 1 | 8.15 |
| CHEMBL275155 | — | — | 1 | 8.10 |
| CHEMBL275600 | — | — | 1 | 8.05 |
| CHEMBL418548 | — | — | 1 | 7.55 |
| CHEMBL17357 | — | — | 1 | 7.52 |
| CHEMBL17872 | — | — | 1 | 7.30 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.12 |
| CHEMBL15564 | — | — | 1 | 7.10 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 7.00 |
| CHEMBL278188 | — | — | 1 | 6.94 |
| CHEMBL441220 | — | — | 1 | 6.00 |
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17231 | — | EC50 | = | 0.028 | nM | 10.55 |
| CHEMBL587 | SKF-89124A | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL17550 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL279106 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL275155 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL275600 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL418548 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL17357 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL17872 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL59 | DOPAMINE | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL15564 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL589 | ROPINIROLE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL278188 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL441220 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL588 | FENOLDOPAM | EC50 | = | 1200.0 | nM | 5.92 |