Assay Detail
Binding
CHEMBL670974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Dopamine receptor D2 in rat striatal membranes using [3H]spiperone
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N,N-6-bis-[2-(3,4-dihydroxybenzyl)pyrrolidinyl]hexane, a potent, selective, orally active dopamine analog with hypotensive and diuretic activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.87 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80369 | — | — | 1 | 8.50 |
| CHEMBL308295 | — | — | 1 | 8.49 |
| CHEMBL310997 | — | — | 1 | 8.21 |
| CHEMBL80974 | — | — | 1 | 8.05 |
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 7.88 |
| CHEMBL80686 | — | — | 1 | 7.83 |
| CHEMBL15564 | — | — | 1 | 7.65 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 7.20 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80369 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL308295 | — | Ki | = | 3.236 | nM | 8.49 |
| CHEMBL310997 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL80974 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL588 | FENOLDOPAM | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL80686 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL15564 | — | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL59 | DOPAMINE | Ki | = | 104.71 | nM | 6.98 |