D(2) dopamine receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P61169. Use UniProt P61169 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P61169 as the stable identity anchor, then attach disease evidence before program review.
D(2) dopamine receptor
Review this target as D(2) dopamine receptor, mapped to UniProt P61169. Sequence length is 444 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats D(2) dopamine receptor as ChEMBL target CHEMBL339, mapped to UniProt P61169. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | D(2) dopamine receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P61169 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | D(2) dopamine receptor |
| UniProt Accession | P61169 |
| Component Type | Protein |
| Sequence Length | 444 aa |
D(2) dopamine receptor
Review this target as D(2) dopamine receptor, mapped to UniProt P61169. Sequence length is 444 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL98305 | 10.89 | EC50 | 0.013 | Preclinical |
| CHEMBL20734 | 10.85 | Kd | 0.014 | Clinical |
| CHEMBL267930 | 10.82 | Ki | 0.015 | Clinical |
| CHEMBL1169525 | 10.77 | Ki | 0.017 | Preclinical |
| CHEMBL289330 | 10.74 | Ki | 0.018 | Preclinical |
| CHEMBL308524 | 10.72 | Ki | 0.019 | Preclinical |
| CHEMBL42953 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL2112608 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL134400 | 10.64 | Ki | 0.023 | Preclinical |
| CHEMBL137648 | 10.64 | Ki | 0.023 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 206 | 1,311 | 7.1 |
| tissue-based format | 181 | 924 | 6.7 |
| assay format | 156 | 758 | 7.0 |
| cell membrane format | 153 | 858 | 7.0 |
| cell-based format | 72 | 455 | 7.0 |
| organism-based format | 16 | 82 | 8.6 |
| subcellular format | 1 | 3 | 5.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 29 | 45 | 7.3 |
| cell-based format | 27 | 53 | 7.0 |
| cell membrane format | 23 | 60 | 7.6 |
| organism-based format | 22 | 0 | — |
| tissue-based format | 8 | 3 | 6.0 |