Review anchor
D(2) dopamine receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
D(2) dopamine receptor
CHEMBL339
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats D(2) dopamine receptor as ChEMBL target CHEMBL339, mapped to UniProt P61169. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL339
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P61169
D(2) dopamine receptor
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why D(2) dopamine receptor matters
D(2) dopamine receptor is reviewed as D(2) dopamine receptor (UniProt P61169); the current evidence base includes 68 approved drugs, 5623 compounds, and 894 assays, with lead potency reaching pChEMBL 10.9.
Protein context
D(2) dopamine receptor
D(2) dopamine receptor Sequence length is 444 aa.
Review this target as D(2) dopamine receptor, mapped to UniProt P61169. Sequence length is 444 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P61169
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 68 approved drugs, 5623 compounds, and 894 assays for this target. The dominant activity type is KI. CHEMBL98305 is the current potency anchor at pChEMBL 10.9.
Use CHEMBL98305 as the tractability anchor when discussing potency (pChEMBL 10.9).
Activity source · ChEMBL 36 via Core Engine
68 approved
pChEMBL 10.9
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why D(2) dopamine receptor matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P61169, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
5623
Total Compounds
894
Total Assays
68
Approved Drugs
IC50: 2427.0, KI: 4194.0, EC50: 121.0, KD: 102.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL98305
|
10.9 | EC50 | — |
|
|
No preferred name
CHEMBL20734
|
10.8 | Kd | Clinical |
|
|
No preferred name
CHEMBL267930
|
10.8 | Ki | Clinical |
|
|
No preferred name
CHEMBL1169525
|
10.8 | Ki | — |
|
|
No preferred name
CHEMBL289330
|
10.7 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
LUMATEPERONE TOSYLATE
CHEMBL3233142
|
2019 |
|
|
CARIPRAZINE HYDROCHLORIDE
CHEMBL2024517
|
2015 |
|
|
BREXPIPRAZOLE
CHEMBL2105760
|
2015 |
|
|
VILAZODONE
CHEMBL439849
|
2011 |
|
|
LURASIDONE
CHEMBL1237021
|
2010 |
|
|
ILOPERIDONE
CHEMBL14376
|
2009 |
|
|
ARIPIPRAZOLE
CHEMBL1112
|
2002 |
|
|
APOMORPHINE
CHEMBL53
|
2001 |
|
|
ZIPRASIDONE
CHEMBL708
|
2001 |
|
|
APOMORPHINE HYDROCHLORIDE
CHEMBL3187985
|
2001 |
|
|
ZOLMITRIPTAN
CHEMBL1185
|
1997 |
|
|
FENOLDOPAM
CHEMBL588
|
1997 |
|
|
ROPINIROLE
CHEMBL589
|
1997 |
|
|
QUETIAPINE
CHEMBL716
|
1997 |
|
|
PRAMIPEXOLE
CHEMBL301265
|
1997 |
|
|
OLANZAPINE
CHEMBL715
|
1996 |
|
|
SERTINDOLE
CHEMBL12713
|
1996 |
|
|
RISPERIDONE
CHEMBL85
|
1993 |
|
|
CISAPRIDE
CHEMBL1729
|
1993 |
|
|
CLOZAPINE
CHEMBL42
|
1989 |
|
|
CLOMIPRAMINE
CHEMBL415
|
1989 |
|
|
PERGOLIDE
CHEMBL531
|
1988 |
|
|
BUSPIRONE
CHEMBL49
|
1986 |
|
|
METOCLOPRAMIDE
CHEMBL86
|
1979 |
|
|
BROMOCRIPTINE
CHEMBL493
|
1978 |
|
|
LOXAPINE
CHEMBL831
|
1975 |
|
|
DOPAMINE
CHEMBL59
|
1974 |
|
|
MOLINDONE
CHEMBL460
|
1974 |
|
|
DOPAMINE HYDROCHLORIDE
CHEMBL1557
|
1974 |
|
|
HALOPERIDOL
CHEMBL54
|
1967 |
|
|
THIORIDAZINE
CHEMBL479
|
1962 |
|
|
CYPROHEPTADINE
CHEMBL516
|
1961 |
|
|
TRIFLUOPERAZINE
CHEMBL422
|
1959 |
|
|
CHLORPROMAZINE
CHEMBL71
|
1957 |
|
|
MIANSERIN
CHEMBL6437
|
— |
Source Header